Your Portfolio
120
20600
6 mo60 mo
20%90%
$500$5,000
$10K$200K
150
Net Annual ROI
$0
0x return
Adjust the sliders to see your estimate.
Time saved
—
months to enrollment per trial
Screen-fail savings
—
annual across portfolio
Delay cost avoided
—
annual across portfolio
Syncra cost
—
annual (subscription + per-patient)
Value breakdown — annual
Screen-fail reduction
$0
Trial delay avoided
$0
Total gross value
$0
Syncra annual cost
$0
Net annual ROI
$0
Enrollment time reduction
Predictive EHR scoring + multi-site coordination benchmarks suggest 30–40% reduction in time-to-full-enrollment for AI-assisted trials. We use 35% as the midpoint.
- Source: Tufts Center for the Study of Drug Development (CSDD) — AI-augmented recruitment lifting site activation and screening velocity
- Source: BIO Clinical Development Success Rates
Screen-fail savings formula
// Screened patients per trial = enrolled ÷ (1 − screen_fail_rate)
screened_per_trial = target_n ÷ (1 − sfr)
// Syncra reduces screen-fail rate by 35% of the overage
// (bad matches filtered before they hit a screening visit)
avoidable_screens = screened_per_trial × sfr × 0.35
sf_savings_per_trial = avoidable_screens × cost_per_screen_visit
annual_sf_savings = sf_savings_per_trial × num_trials
Delay cost avoidance formula
// Time saved per trial (months)
time_saved = enrollment_months × 0.35
// Delay cost = sites × months saved × cost per site per month
delay_savings_per_trial = sites × time_saved × delay_cost_per_site_month
annual_delay_savings = delay_savings_per_trial × num_trials
Default $40,000/site/month is Phase II benchmark from Tufts CSDD (includes site staff, IRB fees, monitoring, and opportunity cost). Phase III typically runs $80K–$120K/site/month.
Syncra pricing
// $3,000/month per active trial network
subscription_cost = num_trials × 3000 × 12
// $400 per enrolled patient across portfolio
per_patient_cost = num_trials × target_n × 400
annual_cost = subscription_cost + per_patient_cost
Net ROI & ROI multiple
gross_value = annual_sf_savings + annual_delay_savings
net_roi = gross_value − annual_cost
roi_multiple = gross_value ÷ annual_cost
ROI multiple is gross value divided by cost — how many dollars returned per dollar spent. Net ROI is the dollar surplus.
What this doesn't include
- Staff time savings (coordinator hours freed from manual chart review — typically 15–20 hrs/week/site)
- Improved data quality and reduced protocol deviations from AI-assisted screening
- Patient retention improvements (Syncra agents maintain engagement post-screen)
- Cross-trial learnings compounding over time
All estimates are conservative. Real-world deployments typically show higher returns once staff reallocation is included.
These numbers real for your portfolio?
Book a 20-minute walkthrough. We'll verify the math against your actual trial data and show you the live dashboard.
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Or explore first:
Enrollment Risk Scorer ·
Protocol Change Analyzer